Log In
Upload
Search
Shoji Novel indoline based acyl CoA cholesterol acyltransferase inhibitor Effects of introducing a

Shoji Novel indoline based acyl CoA cholesterol acyltransferase inhibitor Effects of introducing a.m

size: 489 KB
format: pdf
uploaded by: anonymous
short link:
4. Experimental
4.1. General procedures
Chemicals were obtained from commercial sources and used
without purification. Intermediates 7, N-(1-acetyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide (18) and 12 were synthesized according to the methods previously reported.15,19
Reactions were monitored by thin-layer chromatography (TLC)
on Merck precoated Silica Gel 60 F254 (0.25 mm) plates. Column
chromatography was performed on silica gel (Daiso No.1001 W;
Daiso, Osaka, Japan). Melting points were measured on a melting
point apparatus (MP-21; Yamato Scientific, Tokyo, Japan) and are
uncorrected. Infrared spectra (IR) were obtained with an infrared
spectrometer (FT-720; HORIBA, Kyoto, Japan). Proton nuclear magnetic resonance (1H NMR) spectra were recorded at 400 MHz on a
nuclear magnetic resonance spectrometer (JNM-AL400; JEOL, Tokyo, Japan) using tetramethylsilane as an internal standard. Mass
spectra (MS) were obtained on a QTRAP LC/MS/MS system
(API2000; Applied Biosystems, Foster Ci
Read Online
Upload useful files

Contribute files that were useful for you to 8files.com, so that people around the world can easy find and use them too. Let's create the biggest ever source of knowledge together!

DMCA takedown notice
About Us | Blog | Feedback | Terms of Use | Copyright Policy | Privacy Policy