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Charupant Chemistry of renieramycins Part 8 Synthesis and cytotoxicity evaluation of renieramycin

Charupant Chemistry of renieramycins Part 8 Synthesis and cytotoxicity evaluation of renieramycin.M

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nudibranch Jorunna funebris (Fig. 3).18 The novel structures of renieramycins, together with their remarkable biological activities and
lack of availability from natural sources, have made these compounds extremely attractive and important synthetic targets. The
first total synthesis of renieramycin A (1a) was accomplished by
Fukuyama in 1990.19 To date, two total syntheses of renieramycin
G (1g),20,21 three total syntheses of renieramycin H (1h: cribrostatin
4),22–24 and one total synthesis of 2a have been published.21 However, the structure–activity relationships of renieramycins are relatively unexplored because most synthetic approaches have focused
on their total synthesis.
As part of our search for new metabolites via the isolation and
characterization of biologically active compounds from Thai marine animals, we have reported the isolation and structure elucidation of renieramycin M (1m) in gram scale from the Thai sponge
Xestospongia sp. by pretreatment with potassium cyanide.25
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