Charupant Chemistry of renieramycins Part 8 Synthesis and cytotoxicity evaluation of renieramycin.M
size: 414 KB
uploaded by: anonymous
nudibranch Jorunna funebris (Fig. 3).18 The novel structures of renieramycins, together with their remarkable biological activities and
lack of availability from natural sources, have made these compounds extremely attractive and important synthetic targets. The
ﬁrst total synthesis of renieramycin A (1a) was accomplished by
Fukuyama in 1990.19 To date, two total syntheses of renieramycin
G (1g),20,21 three total syntheses of renieramycin H (1h: cribrostatin
4),22–24 and one total synthesis of 2a have been published.21 However, the structure–activity relationships of renieramycins are relatively unexplored because most synthetic approaches have focused
on their total synthesis.
As part of our search for new metabolites via the isolation and
characterization of biologically active compounds from Thai marine animals, we have reported the isolation and structure elucidation of renieramycin M (1m) in gram scale from the Thai sponge
Xestospongia sp. by pretreatment with potassium cyanide.25
TOP-10 files from this category:
Contribute files that were useful for you to 8files.com, so that people around the world can easy find and use them too. Let's create the biggest ever source of knowledge together!